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Structural insights into acetylated histone ligand recognition by the BDP1 bromodomain of Plasmodium falciparum

31 Oct 2022

Abstract excerpt

Plasmodium falciparum requires a two-host system, moving between Anopheles mosquito and humans, to complete its life cycle. To overcome such dynamic growth conditions its histones undergo various post-translational modifications to regulate gene expression. The P. falciparum Bromodomain Protein 1 (PfBDP1) has been shown to interact with acetylated lysine modifications on histone H3 to regulate the expression of...

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PMID: 36328269
DOI: 10.1016/j.ijbiomac.2022.10.247

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