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Article

Human hepatic organoids for the analysis of human genetic diseases

6 Sept 2017

Abstract excerpt

We developed an in vitro model system where induced pluripotent stem cells (iPSCs) differentiate into 3-dimensional human hepatic organoids (HOs) through stages that resemble human liver during its embryonic development. The HOs consist of hepatocytes, and cholangiocytes, which are organized into epithelia that surround the lumina of bile duct-like structures. The organoids provide a potentially new model for...

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PMID: 28878125
DOI: 10.1172/jci.insight.94954

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