Article

Connexin46 Modulates Cancer Cell Migration Through a Channel- Independent Mechanism

2026-03-26

Abstract excerpt

<title>Abstract</title> <p>Cell migration is a central process in cancer progression and metastatic dissemination. While connexins (Cxs) classically mediate cell–cell communication through the formation of gap junction channels and hemichannels, accumulating evidence supports additional channel-independent roles in tumor cell signaling. Cx46 is a member of the Cx family with a highly restricted expression pattern...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 5b349092-8ce3-59f9-b648-2e8b3cc73dab
DOI: 10.21203/rs.3.rs-9203674/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Connexin46 Modulates Cancer Cell Migration Through a Channel- Independent MechanismDOI 10.21203/rs.3.rs-9203674/v1Read

Cx26 inhibits breast MDA-MB-435 cell tumorigenic properties by a gap junctional intercellular communication-independent mechanism.Semantic proximity Read

Regulation of Connexin Gap Junctions and Hemichannels by Calcium and Calcium Binding Protein Calmodulin.Semantic proximity Read

Cx43 modulates malignant phenotypes in bladder cancer cells via the c-Src/PTEN/FAK axis.Semantic proximity Read

Reduction in gap junction intercellular communication promotes glioma migration.Semantic proximity Read

Connexins Act as Tumor Suppressors in Three-dimensional Mammary Cell Organoids by Regulating Differentiation and AngiogenesisSemantic proximity Read

Unique and redundant connexin contributions to lens development.Semantic proximity Read

Connexin43 inhibits the oncogenic activity of c-Src in C6 glioma cells.Semantic proximity Read

Connexin26-mediated gap junctional communication reverses the malignant phenotype of MCF-7 breast cancer cells.Semantic proximity Read

Focus on lens connexins.Semantic proximity Read

Tissue-specific expression of CD46 isoforms.Semantic proximity Read

Context dependent reversion of tumor phenotype by connexin-43 expression in MDA-MB231 cells and MCF-7 cells: role of β-catenin/connexin43 association.Semantic proximity Read

Changes in gap junctional connexin isoforms during prostate cancer progressionSemantic proximity Read