Article
Connexin43 inhibits the oncogenic activity of c-Src in C6 glioma cells.
Oncogene - 21 Oct 2010
Herrero-González S, Gangoso E, Giaume C, Naus C C, Medina J M, Tabernero A
Abstract excerpt
One of the characteristics of gliomas is a decrease in the expression of connexin43, a protein that forms gap junctions. Restoring connexin43 expression in glioma cells reduces their exacerbated rate of cell growth, although it is not yet known how connexin43 modifies the expression of genes involved in cell proliferation. Here, we show that restoring connexin43 to C6 glioma cells impedes their progression from...
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