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Article

Cx43 modulates malignant phenotypes in bladder cancer cells via the c-Src/PTEN/FAK axis.

Journal of molecular histology - 30 Mar 2026

Chi Qiang, Xu Hui, Li Hongyang, Ma Guang, Li Xiuming

Abstract excerpt

Bladder cancer (BC), a leading urogenital malignancy with high mortality, lacks effective early biomarkers. Connexin 43 (Cx43), encoded by GJA1, regulates tumor growth via protein interactions and phosphorylation. While dysregulated in BC, Cx43's downstream regulatory pathways remain unclear. Elucidating these mechanisms is crucial for identifying novel biomarkers and therapeutic targets. qRT-PCR measured Cx43...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 41910821
DOI: 10.1007/s10735-026-10786-3

Genes

PTEN
GJA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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