Article

Metabolic effects of the schizophrenia-associated 3q29 deletion are sex-specific and uncoupled from behavioral phenotypes

2020-09-20

Abstract excerpt

<h4>SUMMARY</h4> The 1.6 Mb 3q29 deletion is associated with developmental and psychiatric phenotypes. Reduced birthweight and a high prevalence of feeding disorders in patients suggest underlying metabolic dysregulation. We investigated 3q29 deletion-induced metabolic changes using the B6.Del16 +/ Bdh1-Tfrc mouse model. We found that B6.Del16 +/ Bdh1-Tfrc animals preferentially use dietary lipids as an energ...

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Literature Corpus work: 5b2ae499-d21c-5a71-8f46-523ee7a0369a
DOI: 10.1101/2020.09.18.303412

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