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Article

Metabolic effects of the schizophrenia-associated 3q29 deletion.

Translational psychiatry - 17 Feb 2022

Pollak Rebecca M, Purcell Ryan H, Rutkowski Timothy P, Malone Tamika, Pachura Kimberly J, Bassell Gary J, Epstein Michael P, Dawson Paul A, Smith Matthew R, Jones Dean P, Zwick Michael E, Warren Stephen T, Caspary Tamara, Weinshenker David, Mulle Jennifer G

Abstract excerpt

The 1.6 Mb 3q29 deletion is associated with developmental and psychiatric phenotypes, including a 40-fold increased risk for schizophrenia. Reduced birth weight and a high prevalence of feeding disorders in patients suggest underlying metabolic dysregulation. We investigated 3q29 deletion-induced metabolic changes using our previously generated heterozygous B6.Del16+/Bdh1-Tfrc mouse model. Animals were provided...

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Identifiers

PMID: 35177588
DOI: 10.1038/s41398-022-01824-1
PMCID: PMC8854723

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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