Article
Behavioral changes and growth deficits in a CRISPR engineered mouse model of the schizophrenia-associated 3q29 deletion.
Molecular psychiatry - 1 Mar 2021
Rutkowski Timothy P, Purcell Ryan H, Pollak Rebecca M, Grewenow Stephanie M, Gafford Georgette M, Malone Tamika, Khan Uswa A, Schroeder Jason P, Epstein Michael P, Bassell Gary J, Warren Stephen T, Weinshenker David, Caspary Tamara, Mulle Jennifer Gladys
Abstract excerpt
The 3q29 deletion confers increased risk for neuropsychiatric phenotypes including intellectual disability, autism spectrum disorder, generalized anxiety disorder, and a >40-fold increased risk for schizophrenia. To investigate consequences of the 3q29 deletion in an experimental system, we used CRISPR/Cas9 technology to introduce a heterozygous deletion into the syntenic interval on C57BL/6 mouse chromosome 16....
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