Back to search

Article

A Systems Biology Analysis of Chronic Lymphocytic Leukemia

2024-03-28

Abstract excerpt

Whole-genome sequencing has revealed that TP53, NOTCH1, ATM, SF3B1, BIRC3, ABL, NXF1, BCR, ZAP70 are often mutated in CLL, but not consistently across all CLL patients. This paper employs a statistical thermo-dynamics approach in combination with the systems biology of the CLL protein-protein interaction networks to identify the most significant participant proteins in the cancerous transformation. Betti number (a...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
5b1bea15-58a7-5c1a-a523-16dd26af07ed
DOI
10.1101/2024.03.26.586690
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
A Systems Biology Analysis of Chronic Lymphocytic LeukemiaDOI 10.1101/2024.03.26.586690
Constitutive Activation of the B Cell Receptor Underlies Dysfunctional Signaling in Chronic Lymphocytic LeukemiaSemantic proximity
Single-cell Transcriptome Analysis Uncovers Heterogeneity and Key Regulators in Ibrutinib-resistant Chronic Lymphocytic LeukemiaSemantic proximity
Defining the BTK-dependent chromatin-informed gene regulatory network in chronic lymphocytic leukemiaSemantic proximity
Time-series RNA-Seq and data-driven network inference unveil dynamics of cell activation, survival and crosstalk in Chronic Lymphocytic Leukaemia in vitro modelsSemantic proximity
The protein landscape of chronic lymphocytic leukemia.Semantic proximity
Embracing complexity, inching closer to reality.Semantic proximity
Time-series RNA-Seq and data-driven network inference unveil dynamics of cell activation, survival and crosstalk in Chronic Lymphocytic Leukaemia <i>in vitro</i> modelsSemantic proximity
Proteins interaction network and modeling of IGVH mutational status in chronic lymphocytic leukemia.Semantic proximity
A Complex Systems Analysis of Cancer NetworksSemantic proximity
Chromatin mapping and single-cell immune profiling define the temporal dynamics of ibrutinib response in CLLSemantic proximity
A systems biology pipeline identifies new immune and disease related molecular signatures and networks in human cells during microgravity exposureSemantic proximity
Molecular Systems Architecture of Interactome in the Acute Myeloid Leukemia MicroenvironmentSemantic proximity
Select a neighboring publication to make it the new centre.