Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The protein landscape of chronic lymphocytic leukemia.

Blood - 16 Dec 2021

Meier-Abt Fabienne, Lu Junyan, Cannizzaro Ester, Pohly Marcel F, Kummer Sandra, Pfammatter Sibylle, Kunz Laura, Collins Ben C, Nadeu Ferran, Lee Kwang Seok, Xue Peng, Gwerder Myriam, Roiss Michael, Hüllein Jennifer, Scheinost Sebastian, Dietrich Sascha, Campo Elias, Huber Wolfgang, Aebersold Ruedi, Zenz Thorsten

Abstract excerpt

Many functional consequences of mutations on tumor phenotypes in chronic lymphocytic leukemia (CLL) are unknown. This may be in part due to a scarcity of information on the proteome of CLL. We profiled the proteome of 117 CLL patient samples with data-independent acquisition mass spectrometry and integrated the results with genomic, transcriptomic, ex vivo drug response, and clinical outcome data. We found...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DEAD-box RNA Helicases
Share to Gene Expression Regulation, Leukemic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Immunoglobulin Heavy Chains

Share to Immunoglobulin Variable Region

Share to Leukemia, Lymphocytic, Chronic, B-Cell

Share to Proteome

Share to RNA Splicing Factors

Share to Trisomy

Source

Identifiers

PMID: 34189564
DOI: 10.1182/blood.2020009741

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The protein landscape of chronic lymphocytic leukemia.PMID 34189564Read ↗

Proteogenomics refines the molecular classification of chronic lymphocytic leukemia.Semantic proximity Read ↗

Proteogenomics refines the molecular classification of chronic lymphocytic leukemiaSemantic proximity Read ↗

Proteomic profiling based classification of CLL provides prognostication for modern therapy and identifies novel therapeutic targets.Semantic proximity Read ↗

RPPA-based proteomics recognizes distinct epigenetic signatures in chronic lymphocytic leukemia with clinical consequences.Semantic proximity Read ↗

Proteomics Profiling of CLL Versus Healthy B-cells Identifies Putative Therapeutic Targets and a Subtype-independent Signature of Spliceosome DysregulationSemantic proximity Read ↗

The mutational landscape of chronic lymphocytic leukemia and its impact on prognosis and treatmentSemantic proximity Read ↗

Molecular map of chronic lymphocytic leukemia and its impact on outcome.Semantic proximity Read ↗

High-throughput proteomics identifies THEMIS2 as independent biomarker of treatment-free survival in untreated CLLSemantic proximity Read ↗

Trisomy 12 chronic lymphocytic leukemia expresses a unique set of activated and targetable pathways.Semantic proximity Read ↗

Assessing technical and biological variation in SWATH-MS-based proteomic analysis of chronic lymphocytic leukaemia cells.Semantic proximity Read ↗

Molecular pathogenesis of chronic lymphocytic leukemia.Semantic proximity Read ↗

Multipronged functional proteomics approaches for global identification of altered cell signalling pathways in B-cell chronic lymphocytic leukaemia.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.