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Single-cell Transcriptome Analysis Uncovers Heterogeneity and Key Regulators in Ibrutinib-resistant Chronic Lymphocytic Leukemia

2021-11-08

Abstract excerpt

<title>Abstract</title> <p><bold>Background</bold>Ibrutinib as a widely used Bruton’s tyrosine kinase inhibitor has shown outstanding value in clinical therapy for chronic lymphocytic leukemia (CLL). However, the bottleneck of ibrutinib resistance has caused widespread concerns, necessitating the exploration of novel targets. <bold>Methods</bold>Single-cell RNA sequencing (scRNA-seq) was used to characterize the...

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Literature Corpus work
be1fd486-e5ea-5fbd-a9bd-c8523e866cfe
DOI
10.21203/rs.3.rs-998561/v1
Open publication

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Single-cell Transcriptome Analysis Uncovers Heterogeneity and Key Regulators in Ibrutinib-resistant Chronic Lymphocytic LeukemiaDOI 10.21203/rs.3.rs-998561/v1
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