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Time-series RNA-Seq and data-driven network inference unveil dynamics of cell activation, survival and crosstalk in Chronic Lymphocytic Leukaemia <i>in vitro</i> models

2025-04-23

Abstract excerpt

How do cancer cells respond to their environment, and what are the key regulators behind their behaviour? While immune cell reprogramming in the tumour microenvironment (TME) has been extensively studied, the dynamic regulatory changes within cancer cells in response to interactions with immune cells remain poorly understood. In Chronic Lymphocytic Leukaemia (CLL), this knowledge gap limits our ability to fully gr...

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Literature Corpus work
8ae9337f-ad46-531b-a5fe-3a4f14ac7638
DOI
10.1101/2025.04.20.649300
Open publication

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Time-series RNA-Seq and data-driven network inference unveil dynamics of cell activation, survival and crosstalk in Chronic Lymphocytic Leukaemia <i>in vitro</i> modelsDOI 10.1101/2025.04.20.649300
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