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Article

Proteins interaction network and modeling of IGVH mutational status in chronic lymphocytic leukemia.

Theoretical biology & medical modelling - 20 Jun 2015

Álvarez-Silva María Camila, Yepes Sally, Torres Maria Mercedes, Barrios Andrés Fernando González

Abstract excerpt

BACKGROUND: Chronic lymphocytic leukemia (CLL) is an incurable malignancy of mature B-lymphocytes, characterized as being a heterogeneous disease with variable clinical manifestation and survival. Mutational statuses of rearranged immunoglobulin heavy chain variable (IGVH) genes has been consider one of the most important prognostic factors in CLL, but despite of its proven value to predict the course of the...

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Topics

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Share to EGR1 gene
Share to Gene Expression Regulation, Neoplastic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to FOS gene

Share to Immunoglobulin Heavy Chains

Share to Leukemia, Lymphocytic, Chronic, B-Cell

Share to Models, Biological

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Share to Protein Interaction Maps

Source

Open in PubMed Open full text

Identifiers

PMID: 26088082
DOI: 10.1186/s12976-015-0008-z
PMCID: PMC4479082

Genes

FOS
TNF
EGR1
LPL
PTEN
TGFBR3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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