Article

High Resolution ES-DMA quantifies AAV capsid DNA content by electrical mobility to mass correlation

2025-12-12

Abstract excerpt

<title>Abstract</title> <p>Recombinant Adeno-Associated Virus (rAAV) is the leading viral vector platform for gene therapy. A persistent challenge in rAAV manufacturing and quality control is accurate assessment of the DNA content of purified viral capsids. Empty particles, as well as ‘partial’ and over-filled species commonly contaminate even highly purified rAAV preparations. These impurities contribute to high...

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Literature Corpus work: 5b0904fe-8e56-5bb2-ae98-b68a5a3cbbb6
DOI: 10.21203/rs.3.rs-8291101/v1

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