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Development of an icIEF assay for monitoring AAV capsid proteins and application to gene therapy products

10 Mar 2023

Abstract excerpt

Adeno-associated virus (AAV) gene therapy vectors, which contain a DNA transgene packaged into a protein capsid, have shown tremendous therapeutic potential in recent years. Methods traditionally used in quality control labs, such as high-performance liquid chromatography (HPLC) and capillary electrophoresis (CE), do not provide a complete understanding of capsid viral protein (VP) charge heterogeneity. In the...

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PMID: 37025949
DOI: 10.1016/j.omtm.2023.03.002

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