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Quantification of Empty, Partially Filled and Full Adeno-Associated Virus Vectors Using Mass Photometry

3 Jul 2023

Abstract excerpt

Adeno-associated viruses (AAV) are one of the most commonly used vehicles in gene therapies for the treatment of rare diseases. During the AAV manufacturing process, particles with little or no genetic material are co-produced alongside the desired AAV capsid containing the transgene of interest. Because of the potential adverse health effects of these byproducts, they are considered impurities and need to be...

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PMID: 37446211
DOI: 10.3390/ijms241311033

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