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Analytical Strategies for Quantification of Adeno-Associated Virus Empty Capsids to Support Process Development

1 Aug 2019

Abstract excerpt

Recombinant adeno-associated virus (rAAV)-mediated gene therapy is a fast-evolving field in the biotechnology industry. One of the major challenges in developing a purification process for AAV gene therapy is establishing an effective yet scalable method to remove empty capsids, or viral vectors lacking the therapeutic gene, from full capsids-viral product containing the therapeutic sequence. Several analytical...

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PMID: 31368356
DOI: 10.1089/hgtb.2019.088

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