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Assessing production variability in empty and filled adeno-associated viruses by single molecule mass analyses

14 Nov 2022

Abstract excerpt

Adeno-associated viruses (AAVs) are useful vehicles for gene therapy because of their stability, low immunogenicity. and non-pathogenicity. However, disparity in AAV sample preparations (e.g., in capsid composition, DNA packaging, and impurities) gives rise to product heterogeneity, with possibly undesired effects on gene delivery. Ideally, AAV production should be with full control of AAV structure and genetic...

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PMID: 36458114
DOI: 10.1016/j.omtm.2022.11.003

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