Article

Spectral Interferences Impede the High-Resolution Mass Analysis of Recombinant Adeno-Associated Viruses

2022-08-27

Abstract excerpt

Recombinant adeno-associated viruses (rAAVs) are the leading platform for in vivo delivery of gene therapies, with several already approved for clinical use. However, the heterogeneity and structural complexity of these viral particles render them challenging targets to characterize. Orbitrap-based native mass spectrometry (MS) is a method capable of directly characterizing intact megadalton protein assemblies. H...

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Literature Corpus work: 1498f9ac-1de1-55d9-8339-67d11db709ee
DOI: 10.1101/2022.08.27.505551

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