Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A possible role for humoral immunity in the pathogenesis of Parkinson's disease.

Brain : a journal of neurology - 1 Nov 2005

Orr Carolyn F, Rowe Dominic B, Mizuno Yoshikuni, Mori Hideo, Halliday Glenda M

Abstract excerpt

The pathogenesis of idiopathic Parkinson's disease is unknown, but nigral degeneration and depigmentation are associated with microglial inflammation and anti-inflammatory medications appear to protect against the disease. The possibility that humoral immunity may play a role in initiating or regulating the inflammation has been suggested by experimental studies triggering dopamine cell death using a variety of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to alpha-Synuclein
Share to Immunoglobulin G
Share to Immunoglobulin M

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Lewy Bodies

Share to Microglia

Share to Receptors, IgG

Share to Substantia Nigra

Share to Visual Cortex

Source

Identifiers

PMID: 16219675
DOI: 10.1093/brain/awh625

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A possible role for humoral immunity in the pathogenesis of Parkinson's disease.PMID 16219675Read ↗

Exploring neuro-immune interactions in neurodegeneration : the role of B lymphocytes in Parkinson's diseaseSemantic proximity Read ↗

The role of innate and adaptive immunity in Parkinson's disease.Semantic proximity Read ↗

Brain injury contributes to dopaminergic neurodegeneration, Lewy body pathology, and Parkinsonism preclinically with outcomes altered by T cell modulationSemantic proximity Read ↗

The Role of Immune Dysfunction in Parkinson's Disease DevelopmentSemantic proximity Read ↗

Peripheral Immune pattern in a genetic cohort of p.A53T alpha-synuclein Parkinson’s diseaseSemantic proximity Read ↗

Neuroinflammation in Parkinson's disease: role in neurodegeneration and tissue repair.Semantic proximity Read ↗

The biological basis of heterogeneity in Parkinson's disease : insights from an innate immune perspectiveSemantic proximity Read ↗

Adaptive Immunity and Parkinson's Disease.Semantic proximity Read ↗

A Possible Role for HSV-1-Specific Humoral Response and PILRA rs1859788 Polymorphism in the Pathogenesis of Parkinson’s DiseaseSemantic proximity Read ↗

Infiltrating Peripheral Monocyte TREM-1 Mediates Dopaminergic Neuron Injury in Substantia Nigra of Parkinson's Disease Model MiceSemantic proximity Read ↗

A potential link between autoimmunity and neurodegeneration in immune-mediated neurological diseaseSemantic proximity Read ↗

Reduced T helper and B lymphocytes in Parkinson's diseaseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.