Protein Language Model Based Structure-guided Antibody Screening for Disordered Protein Targets

Abstract excerpt

A crucial step in the pathogenesis of Parkinson’s disease involves cell-to-cell transmission of α -Synuclein proto-fibrils via endocytosis, driven primarily by the interaction of its disordered C-terminal peptide with domain 1 of Lymphocyte Activation Gene 3 (LAG3) neuronal receptors. High-affinity antibodies have been proposed as therapeutic modalities to delay this progression and subsequent amyloid formation....

Topics

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• Amino Acid Sequence
• Antibodies
• Computational Biology
• Germ-Line Mutation
• Glycosylation and Glycoproteins Research
• Monoclonal and Polyclonal Antibodies Research
• Mutation
• vaccines and immunoinformatics approaches

Identifiers and source

Literature Corpus work

5ae4c4a9-2896-52d4-a2a4-efd490bc0bc3

DOI

10.1101/2025.06.21.660895