Article

Hepatocyte CREBZF-osteopontin axis controls fibrosis in nonalcoholic steatohepatitis

2021-09-29

Abstract excerpt

<title>Abstract</title> <p>Nonalcoholic steatohepatitis (NASH) has emerged as a leading cause of chronic liver disease. The incomplete understanding of NASH fibrosis limits pharmacotherapy development. Here we report a molecular link between hepatocytes and hepatic stellate cells (HSCs) in regulating the progression of liver fibrosis via CREBZF-osteopontin (OPN) axis. Hepatocyte-specific CREBZF knockout (CREBZF L...

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Literature Corpus work: 4093a300-151d-5d3e-b3e8-490f078421de
DOI: 10.21203/rs.3.rs-929976/v1

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