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Article

Multi-omics characterization of a diet-induced obese model of non-alcoholic steatohepatitis

24 Jan 2020

Abstract excerpt

To improve the understanding of the complex biological processes underlying the development of non-alcoholic steatohepatitis (NASH), a multi-omics approach combining bulk RNA-sequencing based transcriptomics, quantitative proteomics and single-cell RNA-sequencing was used to characterize tissue biopsies from histologically validated diet-induced obese (DIO) NASH mice compared to chow-fed controls. Bulk...

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Cancer-related molecular mechanisms research
Lipid metabolism and disorders
Liver Disease Diagnosis and Treatment

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 31980690
DOI: 10.1038/s41598-020-58059-7

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