Accelerated APOA-II senile amyloidosis in a <i>PAI-1</i> (plasminogen activator inhibitor 1) knock-out model

Abstract excerpt

Apolipoprotein A-II amyloidosis (AApoA-II) is the most common form of age-related amyloidosis in mice, typically arising sporadically in aged animals or in senescence-accelerated strains carrying the APOA2C variant. Here, we report that plasminogen activator inhibitor-1 deficient (PAI-1 −/− ) mice develop systemic AApoA-II amyloidosis with complete penetrance at an intermediate age. Congo red-positive deposits we...

Topics

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• Amyloidosis
• Apolipoproteins A
• Inflammation Mediators
• Pituitary Adenylate Cyclase-Activating Polypeptide
• Plaque, Amyloid
• Proteomics
• Severity of Illness Index
• Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization

Identifiers and source

Literature Corpus work

5ab4566d-6757-506b-bdb4-d882e9138a26

DOI

10.64898/2025.12.18.695159