Article
Tissue distribution, biochemical properties, and transmission of mouse type A AApoAII amyloid fibrils.
The American journal of pathology - 1 May 2004
Korenaga Tatsumi, Fu Xiaoying, Xing Yanming, Matsusita Takatoshi, Kuramoto Kazunao, Syumiya Seigo, Hasegawa Kazuhiro, Naiki Hironobu, Ueno Masaki, Ishihara Tokuhiro, Hosokawa Masanori, Mori Masayuki, Higuchi Keiichi
Abstract excerpt
In mouse strains with the amyloidogenic apolipoprotein A-II (ApoA-II) gene (Apoa2c), the type C ApoA-II protein (APOAIIC) associates to form amyloid fibrils AApoAII(C) that lead to development of early onset and systemic amyloidosis with characteristic heavy amyloid deposits in the liver and spleen. We found age-associated heavy deposition of amyloid fibrils [AApoAII(A)] composed of type A ApoA-II protein...
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