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Article

Accelerated pre-senile systemic amyloidosis in PACAP knockout mice - a protective role of PACAP in age-related degenerative processes.

The Journal of pathology - 1 Aug 2018

Reglodi Dora, Jungling Adel, Longuespée Rémi, Kriegsmann Joerg, Casadonte Rita, Kriegsmann Mark, Juhasz Tamas, Bardosi Sebastian, Tamas Andrea, Fulop Balazs Daniel, Kovacs Krisztina, Nagy Zsuzsanna, Sparks Jason, Miseta Attila, Mazzucchelli Gabriel, Hashimoto Hitoshi, Bardosi Attila

Abstract excerpt

Dysregulation of neuropeptides may play an important role in aging-induced impairments. Among them, pituitary adenylate cyclase-activating polypeptide (PACAP) is a potent cytoprotective peptide that provides an endogenous control against a variety of tissue-damaging stimuli. We hypothesized that the progressive decline of PACAP throughout life and the well-known general cytoprotective effects of PACAP lead to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29774542
DOI: 10.1002/path.5100
PMCID: PMC6055756

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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