Article
Accelerated senile amyloidosis induced by amyloidogenic Apoa-II gene shortens the life span of mice but does not accelerate the rate of senescence.
The journals of gerontology. Series A, Biological sciences and medical sciences - 1 Jul 1996
Higuchi K, Wang J, Kitagawa K, Matsushita T, Kogishi K, Naiki H, Kitado H, Hosokawa M
Abstract excerpt
The SAMP1 strain is a mouse model for accelerated senescence and severe senile amyloidosis. We studied the effects of the amyloidogenic apolipoprotein A-II gene (Apoa2c) on senile amyloidosis and the life span and progress of senescence of congenic mice (R1.P1-Apoa2c) which have Apoa2c of the SAMPI strain on the genome of the normally aging SAMR1 strain. Age-associated and severe amyloid deposits were detected in...
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