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mTOR Signalling in Arbovirus Infections: Molecular Mechanisms and Therapeutic Opportunities

1 May 2025

Abstract excerpt

Arboviruses, including dengue virus (DENV), Zika virus (ZIKV), Japanese encephalitis virus (JEV), and West Nile virus (WNV), are vector-borne pathogens that exploit the mammalian target of rapamycin (mTOR) signalling pathway to optimise host cellular environments for replication, immune evasion, and pathogenesis. These viruses manipulate mTOR complexes through specific viral proteins, such as DENV NS5 activating...

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PMID: 40317563
DOI: 10.1002/rmv.70037

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