Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Rapamycin relieves lentiviral vector transduction resistance in human and mouse hematopoietic stem cells

10 Jun 2014

Abstract excerpt

Transplantation of genetically modified hematopoietic stem cells (HSCs) is a promising therapeutic strategy for genetic diseases, HIV, and cancer. However, a barrier for clinical HSC gene therapy is the limited efficiency of gene delivery via lentiviral vectors (LVs) into HSCs. We show here that rapamycin, an allosteric inhibitor of the mammalian target of rapamycin complexes, facilitates highly efficient...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CAR-T cell therapy research
Share to CRISPR and Genetic Engineering
Share to Virus-based gene therapy research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 24914132
DOI: 10.1182/blood-2013-12-546218

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Rapamycin relieves lentiviral vector transduction resistance in human and mouse hematopoietic stem cellsPMID 24914132Read ↗

Advancements in Hematopoietic Stem Cell Gene Therapy: A Journey of Progress for Viral TransductionSemantic proximity Read ↗

Cyclosporin a and rapamycin relieve distinct lentiviral restriction blocks in hematopoietic stem and progenitor cells.Semantic proximity Read ↗

CAR Gene Delivery by T‐cell Targeted Lentiviral Vectors is Enhanced by Rapamycin Induced Reduction of Antiviral MechanismsSemantic proximity Read ↗

Lentiviral vectors escape innate sensing but trigger p53 in human hematopoietic stem and progenitor cellsSemantic proximity Read ↗

Recent advances in lentiviral vector development and applications.Semantic proximity Read ↗

Removal of innate immune barriers allows efficient transduction of quiescent human hematopoietic stem cellsSemantic proximity Read ↗

Assessing the Impact of Cyclosporin A on Lentiviral Transduction and Preservation of Human Hematopoietic Stem Cells in Clinically Relevant Ex Vivo Gene Therapy SettingsSemantic proximity Read ↗

Rapamycin Enhances CAR-T Control of HIV Replication and Reservoir Elimination <i>in vivo</i>Semantic proximity Read ↗

Ex vivo long-term expansion of human hematopoietic stem and progenitor cells as a tool for modeling vector integration sites and clonalitySemantic proximity Read ↗

Integration-deficient lentiviral vectors: a slow coming of age.Semantic proximity Read ↗

Proteasome activity restricts lentiviral gene transfer into hematopoietic stem cells and is down-regulated by cytokines that enhance transductionSemantic proximity Read ↗

Rapid lentiviral transduction preserves the engraftment potential of Fanca(-/-) hematopoietic stem cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.