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Article

Cyclosporin a and rapamycin relieve distinct lentiviral restriction blocks in hematopoietic stem and progenitor cells.

Molecular therapy : the journal of the American Society of Gene Therapy - 1 Feb 2015

Petrillo Carolina, Cesana Daniela, Piras Francesco, Bartolaccini Sara, Naldini Luigi, Montini Eugenio, Kajaste-Rudnitski Anna

Abstract excerpt

Improving hematopoietic stem and progenitor cell (HSPC) permissiveness to HIV-derived lentiviral vectors (LVs) remains a challenge for the field of gene therapy as high vector doses and prolonged ex vivo culture are still required to achieve clinically relevant transduction levels. We report here that Cyclosporin A (CsA) and Rapamycin (Rapa) significantly improve LV gene transfer in human and murine HSPC. Both...

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Source

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Identifiers

PMID: 25270076
DOI: 10.1038/mt.2014.193
PMCID: PMC4312494

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Cyclosporin a and rapamycin relieve distinct lentiviral restriction blocks in hematopoietic stem and progenitor cells.PMID 25270076Read ↗

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