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Cell-Free DNA Sequencing Uncovers the Longitudinal Consequences of Temozolomide Treatment and Host Co-Culture in Glioblastoma

2025-07-12

Abstract excerpt

<h4>ABSTRACT</h4> Glioblastoma (GBM) is a highly aggressive brain tumor with limited options for longitudinal monitoring. We evaluated the potential of cell-free DNA (cfDNA) as a real-time biomarker of tumor burden under tightly controlled conditions. We measured the cfDNA release dynamics, fragmentation sizes, and variant allele frequencies (VAF) in patient-derived GBM cell cultures. Time series of cfDNA were co...

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Literature Corpus work: 5aa99ed8-b1ee-5ba6-8c49-de49f48cdb4a
DOI: 10.1101/2025.07.12.662613

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