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Detection of Brain Cancer Using Genome-wide Cell-free DNA Fragmentomes

29 Apr 2025

Abstract excerpt

Diagnostic delays in patients with brain cancer are common and can impact patient outcome. Development of a blood-based assay for detection of brain cancers could accelerate brain cancer diagnosis. In this study, we analyzed genome-wide cell-free (cfDNA) fragmentomes, including fragmentation profiles and repeat landscapes, from the plasma of individuals with (n = 148) or without (n = 357) brain cancer. Machine...

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PMID: 40299319
DOI: 10.1158/2159-8290.cd-25-0074

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