Article
Detection of gene mutations and gene-gene fusions in circulating cell-free DNA of glioblastoma patients: an avenue for clinically relevant diagnostic analysis.
Molecular oncology - 1 May 2022
Palande Vikrant, Siegal Tali, Detroja Rajesh, Gorohovski Alessandro, Glass Rainer, Flueh Charlotte, Kanner Andrew A, Laviv Yoseph, Har-Nof Sagi, Levy-Barda Adva, Viviana Karpuj Marcela, Kurtz Marina, Perez Shira, Raviv Shay Dorith, Frenkel-Morgenstern Milana
Abstract excerpt
Glioblastoma (GBM) is the most common type of glioma and is uniformly fatal. Currently, tumour heterogeneity and mutation acquisition are major impedances for tailoring personalized therapy. We collected blood and tumour tissue samples from 25 GBM patients and 25 blood samples from healthy controls. Cell-free DNA (cfDNA) was extracted from the plasma of GBM patients and from healthy controls. Tumour DNA was...
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