Article
Fragmentation patterns and personalized sequencing of cell-free DNA in urine and plasma of glioma patients.
EMBO molecular medicine - 9 Aug 2021
Mouliere Florent, Smith Christopher G, Heider Katrin, Su Jing, van der Pol Ymke, Thompson Mareike, Morris James, Wan Jonathan C M, Chandrananda Dineika, Hadfield James, Grzelak Marta, Hudecova Irena, Couturier Dominique-Laurent, Cooper Wendy, Zhao Hui, Gale Davina, Eldridge Matthew, Watts Colin, Brindle Kevin, Rosenfeld Nitzan, Mair Richard
Abstract excerpt
Glioma-derived cell-free DNA (cfDNA) is challenging to detect using liquid biopsy because quantities in body fluids are low. We determined the glioma-derived DNA fraction in cerebrospinal fluid (CSF), plasma, and urine samples from patients using sequencing of personalized capture panels guided by analysis of matched tumor biopsies. By sequencing cfDNA across thousands of mutations, identified individually in...
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