Article

Epigenetic attenuation of interferon signaling drives aging-related improvements in systemic lupus

2025-01-28

Abstract excerpt

In the general human population, aging is associated with a rise in systemic inflammation, primarily involving innate immune pathways related to interferon (IFN), toll-like receptor, and cytokine signaling. In systemic lupus erythematosus (SLE), a prototypical systemic autoimmune disease, aging is distinctly associated with improvements in disease activity, suggesting a unique relationship between aging and inflam...

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Literature Corpus work: 5a8e34df-0c98-5682-a5da-aaf68ec98d01
DOI: 10.1101/2025.01.27.25321143

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