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Epigenetic attenuation of interferon signaling is associated with aging-related improvements in systemic lupus erythematosus

25 Jun 2025

Abstract excerpt

In the general population, aging is associated with an increase in systemic inflammation and chronic disease burden. However, in systemic lupus erythematosus (SLE), older age is uniquely associated with a decrease in disease activity, suggesting a distinct relationship between aging and inflammation. Using a multiomic approach, we compared aging-related changes in the peripheral blood immune profiles of 287...

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PMID: 40561001
DOI: 10.1126/scitranslmed.adt5550

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