Article

Whole Genome Sequencing of Familial Non-Medullary Thyroid Cancer Identifies Germline Alterations in MAPK/ERK and PI3K/AKT Signaling Pathways

2019-10-13

Abstract excerpt

Evidence of familial inheritance in non-medullary thyroid cancer (NMTC) has accumulated over the last few decades. However, known variants account for a very small percentage of the genetic burden. Here, we focused on the identification of common pathways and networks enriched in NMTC families to better understand its pathogenesis with the final aim of identifying one novel high/moderate-penetrance germline predis...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 5a608cee-5c48-5f2a-97dd-e4b48e5fb41e
DOI: 10.20944/preprints201910.0154.v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Whole Genome Sequencing of Familial Non-Medullary Thyroid Cancer Identifies Germline Alterations in MAPK/ERK and PI3K/AKT Signaling PathwaysDOI 10.20944/preprints201910.0154.v1Read

Whole Genome Sequencing of Familial Non-Medullary Thyroid Cancer Identifies Germline Alterations in MAPK/ERK and PI3K/AKT Signaling PathwaysSemantic proximity Read

Whole exome and target sequencing identifies MAP2K5 as novel susceptibility gene for familial non-medullary thyroid carcinoma.Semantic proximity Read

Identification of susceptibility gene mutations associated with the pathogenesis of familial nonmedullary thyroid cancer.Semantic proximity Read

Genetics of Familial Non-Medullary Thyroid Carcinoma (FNMTC)Semantic proximity Read

Identification of Rare Variants Predisposing to Thyroid CancerSemantic proximity Read

Whole Genome Sequencing Prioritizes CHEK2, EWSR1, and TIAM1 as Possible Predisposition Genes for Familial Non-Medullary Thyroid Cancer.Semantic proximity Read

The Genomic Landscape of Thyroid Cancer Tumourigenesis and Implications for Immunotherapy.Semantic proximity Read

Genomic alterations in thyroid cancer: biological and clinical insights.Semantic proximity Read

Identification of Rare Noncoding Variants in Familial Nonmedullary Thyroid Carcinoma.Semantic proximity Read

Identification of SPRY4 as a Novel Candidate Susceptibility Gene for Familial Nonmedullary Thyroid Cancer.Semantic proximity Read

Prevalence of the major thyroid cancer-associated syndromes in the United StatesSemantic proximity Read

Detection of Molecular Alterations in Taiwanese Patients with Medullary Thyroid Cancer Using Whole-Exome Sequencing.Semantic proximity Read