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Article

Identification of SPRY4 as a Novel Candidate Susceptibility Gene for Familial Nonmedullary Thyroid Cancer.

Thyroid : official journal of the American Thyroid Association - 1 Sept 2021

Marques Inês J, Gomes Inês, Pojo Marta, Pires Carolina, Moura Margarida M, Cabrera Rafael, Santos Catarina, van IJcken Wilfred F J, Teixeira Manuel R, Ramalho José S, Leite Valeriano, Cavaco Branca M

Abstract excerpt

Background: The molecular basis of familial nonmedullary thyroid cancer (FNMTC) is still poorly understood, representing a limitation for molecular diagnosis and clinical management. In this study, we aimed to identify new susceptibility genes for FNMTC through whole-exome sequencing (WES) analysis of leukocyte DNA of patients from a highly informative FNMTC family. Methods: We selected six affected family...

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PMID: 33906393
DOI: 10.1089/thy.2020.0290

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