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Whole Genome Sequencing Prioritizes CHEK2, EWSR1, and TIAM1 as Possible Predisposition Genes for Familial Non-Medullary Thyroid Cancer.

Frontiers in endocrinology - 1 Jan 2021

Srivastava Aayushi, Giangiobbe Sara, Skopelitou Diamanto, Miao Beiping, Paramasivam Nagarajan, Diquigiovanni Chiara, Bonora Elena, Hemminki Kari, Försti Asta, Bandapalli Obul Reddy

Abstract excerpt

Familial inheritance in non-medullary thyroid cancer (NMTC) is an area that has yet to be adequately explored. Despite evidence suggesting strong familial clustering of non-syndromic NMTC, known variants still account for a very small percentage of the genetic burden. In a recent whole genome sequencing (WGS) study of five families with several NMTCs, we shortlisted promising variants with the help of our...

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Identifiers

PMID: 33692755
DOI: 10.3389/fendo.2021.600682
PMCID: PMC7937922

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