Article
Detection of Molecular Alterations in Taiwanese Patients with Medullary Thyroid Cancer Using Whole-Exome Sequencing.
Endocrine pathology - 1 Dec 2018
Chang Ya-Sian, Chang Chun-Chi, Huang Hsi-Yuan, Lin Chien-Yu, Yeh Kun-Tu, Chang Jan-Gowth
Abstract excerpt
Genetic and epigenetic alterations are associated with the progression and prognosis of medullary thyroid carcinoma (MTC). We performed whole-exome sequencing of tumor tissue from seven patients with sporadic MTC using an Illumina HiSeq 2000 sequencing system. We conducted Sanger sequencing to confirm the somatic mutations in both tumor and matched normal tissues. We applied Kyoto Encyclopedia of Genes and...
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