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AMPK/SIRT1 Pathway is Involved in Selenoprotein H Mediated Protective Effects Against Hyperglycemia- Exacerbated Cerebral Ischemia Injury

2026-07-01

Abstract excerpt

<title>Abstract</title> <p>Hyperglycemia markedly exacerbates cerebral ischemia/reperfusion (I/R) injury, yet the underlying neuroprotective mechanism of selenium remains poorly defined. This study investigates whether sodium selenite (Se) promotes mitochondrial biogenesis via the selenoprotein H (SelH)-mediated AMPK/SIRT1/PGC-1α signaling pathway to alleviate hyperglycemia-aggravated cerebral I/R injury. In a st...

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Literature Corpus work
5a40f77e-3b8c-57c0-8df9-4109c7098c5c
DOI
10.21203/rs.3.rs-10130722/v1
Open publication

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