Article

Neuroprotective Effects of Oxymatrine via Triggering Autophagy and Inhibiting Apoptosis Following Spinal Cord Injury in Rats

2022-04-26

Abstract excerpt

<title>Abstract</title> <p>The identification of drugs that promote autophagy and inhibits apoptosis in neurons is critical for improving patient outcomes following spinal cord injury (SCI). Here, we aimed to investigate the neuroprotective effects of oxymatrine (OMT) and the potential mechanism after SCI in rats. Female Sprague-Dawley rats were randomly assigned to either a sham group, SCI group, OMT-treated gro...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 0d962f56-f32e-5a02-9455-2d513eb88f6e
DOI: 10.21203/rs.3.rs-1553538/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Neuroprotective Effects of Oxymatrine via Triggering Autophagy and Inhibiting Apoptosis Following Spinal Cord Injury in RatsDOI 10.21203/rs.3.rs-1553538/v1Read

Tauroursodeoxycholic Acid Alleviates Secondary Injury in Spinal Cord Injury Mice Through Reducing Oxidative Stress, Apoptosis, and Inflammatory ResponseSemantic proximity Read

Autophagy and Apoptosis in Acute Brain Injuries: From Mechanism to TreatmentSemantic proximity Read

GDF‐11 Protects the Traumatically Injured Spinal Cord by Suppressing Pyroptosis and Necroptosis via TFE3‐Mediated Autophagy AugmentationSemantic proximity Read

Down-regulated miR-10a protects against spinal cord injury by up-regulating SIRT1Semantic proximity Read

Ferrostatin-1 Alleviates White Matter Injury via Decreasing Ferroptosis Following Spinal Cord InjurySemantic proximity Read

Mitochondrial Transcription Factor A Delays Neurodegenerative Muscle Atrophy by Regulating Mitochondrial AutophagySemantic proximity Read

Tetramethylpyrazine protects mitochondrial function by upregulating TFAM and alleviating nerve cell apoptosis in SBI ratsSemantic proximity Read

Isorhamnetin promotes functional recovery in rats with spinal cord injury by abating oxidative stress and modulating M2 macrophages/microglia polarization.Semantic proximity Read

The Impact of Environmental Enrichment on Neurological Damage: Mechanistic Study of Ferroptosis Inhibition via Tlr4Semantic proximity Read

Identification of Ferroptotic Genes in Spinal Cord Injury at Different Time Points: Bioinformatics and Experimental ValidationSemantic proximity Read

Effects of spinal cord injury associated exosomes delivered tRF-41 on the progression of spinal cord injury progressionSemantic proximity Read

Mechanical stress regulates autophagic flux to affect apoptosis after spinal cord injurySemantic proximity Read