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Article

Signal Transduction by the TGF-β Superfamily

31 May 2002

Abstract excerpt

Transforming growth factor-beta (TGF-beta) superfamily members regulate a plethora of developmental processes, and disruption of their activity has been implicated in a variety of human diseases ranging from cancer to chondrodysplasias and pulmonary hypertension. Intense investigations have revealed that SMAD proteins constitute the basic components of the core intracellular signaling cascade and that SMADs...

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PMID: 12040180
DOI: 10.1126/science.1071809

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