Article

Decreased brain pH correlated with progression of Alzheimer’s disease neuropathology: a systematic review and meta-analyses of postmortem studies

2024-05-02

Abstract excerpt

<h4>Background</h4> Altered brain energy metabolism is implicated in Alzheimer’s disease (AD). Limited and conflicting studies on brain pH changes, indicative of metabolic alterations associated with neural activity, warrant a comprehensive investigation into their relevance in this neurodegenerative condition. Furthermore, the relationship between these pH changes and established AD neuropathological evaluations,...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 792a15fc-a2d6-5ade-b401-8990055422be
DOI: 10.1101/2024.04.30.24306603

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Decreased brain pH correlated with progression of Alzheimer’s disease neuropathology: a systematic review and meta-analyses of postmortem studiesDOI 10.1101/2024.04.30.24306603Read

Longitudinal analysis of UK Biobank participants suggests age and APOE-dependent alterations of energy metabolism in development of dementiaSemantic proximity Read

The Associations of Serum Valine with Mild Cognitive Impairment and Alzheimer’s DiseaseSemantic proximity Read

Serum metabolic signatures for Alzheimer’s Disease reveal alterations in amino acid composition and energy metabolism – A validation studySemantic proximity Read

Histone Methylation, Energy Metabolism, and Alzheimer's DiseaseSemantic proximity Read

Understanding Proton Magnetic Resonance Spectroscopy Neurochemical Changes using Alzheimer’s Disease Biofluid, PET, Postmortem Pathology Biomarkers and APOE GenotypeSemantic proximity Read

Understanding Proton Magnetic Resonance Spectroscopy Neurochemical Changes Using Alzheimer's Disease Biofluid, PET, Postmortem Pathology Biomarkers, and APOE Genotype.Semantic proximity Read

Non-linear and time-domain sleep qEEG features predict CSF protein damage markers in early Alzheimer’s diseaseSemantic proximity Read

Sex and APOE ε4 genotype modify the Alzheimer's disease serum metabolome.Semantic proximity Read

Metabolic phenotyping reveals an emerging role of ammonia abnormality in Alzheimer's disease.Semantic proximity Read

3-Hydroxybutyrate, A Metabolite in Sustaining Neuronal Cell Vitality: A Mendelian Randomization and in Vitro ExperimentationSemantic proximity Read

Cancer and Alzheimer’s disease: intracellular pH scales the metabolic disordersSemantic proximity Read

Elevated blood glucose levels are associated with the progression of brain hypometabolism, and HDL-C and<i>APOE4</i>add to this associationSemantic proximity Read