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Article

The longevity gene Klotho and its cerebrospinal fluid protein profiles as a modifier for Parkinson´s disease

16 Jan 2021

Abstract excerpt

BACKGROUND: Parkinson´s disease (PD) has a large phenotypic variability, which may, at least partly, be genetically driven including alterations of gene products. Candidates might not only be proteins associated with disease risk but also pathways that play a role in aging. OBJECTIVE: To evaluate phenotype-modifying effects of genetic variants in Klotho, a longevity gene. METHODS: We analyzed two longitudinal...

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PMID: 33449400
DOI: 10.1111/ene.14733

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