Article

Evolutionary constraints limit additional mammalian adaptation of bovine-derived H5N1 influenza viruses in ferrets

2026-07-22

Abstract excerpt

The outbreak of clade 2.3.4.4b H5N1 viruses among U.S. dairy cattle has raised concerns that sustained circulation among agricultural mammals could facilitate viral adaptation toward efficient human transmission. However, the evolutionary dynamics governing such adaptation remain poorly understood. Here we investigated the evolution of two bovine-derived H5N1 B3.13 genotype viruses during infection and airborne tr...

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Literature Corpus work: 828039bd-35b3-56c4-8216-7706b6485cc8
DOI: 10.64898/2026.07.20.739655

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