Article
Selection on haemagglutinin imposes a bottleneck during mammalian transmission of reassortant H5N1 influenza viruses.
Nature communications - 1 Jan 2013
Wilker Peter R, Dinis Jorge M, Starrett Gabriel, Imai Masaki, Hatta Masato, Nelson Chase W, O'Connor David H, Hughes Austin L, Neumann Gabriele, Kawaoka Yoshihiro, Friedrich Thomas C
Abstract excerpt
The emergence of human-transmissible H5N1 avian influenza viruses poses a major pandemic threat. H5N1 viruses are thought to be highly genetically diverse both among and within hosts; however, the effects of this diversity on viral replication and transmission are poorly understood. Here we use deep sequencing to investigate the impact of within-host viral variation on adaptation and transmission of H5N1 viruses...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.