Mammalian adaptation of influenza A(H7N9) virus is limited by a narrow genetic bottleneck.

doi:10.1038/ncomms7553

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Article

Mammalian adaptation of influenza A(H7N9) virus is limited by a narrow genetic bottleneck.

Nature communications - 8 Apr 2015

Zaraket Hassan, Baranovich Tatiana, Kaplan Bryan S, Carter Robert, Song Min-Suk, Paulson James C, Rehg Jerold E, Bahl Justin, Crumpton Jeri C, Seiler Jon, Edmonson Michael, Wu Gang, Karlsson Erik, Fabrizio Thomas, Zhu Huachen, Guan Yi, Husain Matloob, Schultz-Cherry Stacey, Krauss Scott, McBride Ryan, Webster Robert G, Govorkova Elena A, Zhang Jinghui, Russell Charles J, Webby Richard J

Abstract excerpt

Human infection with avian influenza A(H7N9) virus is associated mainly with the exposure to infected poultry. The factors that allow interspecies transmission but limit human-to-human transmission are unknown. Here we show that A/Anhui/1/2013(H7N9) influenza virus infection of chickens (natural hosts) is asymptomatic and that it generates a high genetic diversity. In contrast, diversity is tightly restricted in...

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PMID: 25850788
DOI: 10.1038/ncomms7553
PMCID: PMC4403340

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