Article
Stochastic processes constrain the within and between host evolution of influenza virus.
eLife - 3 May 2018
McCrone John T, Woods Robert J, Martin Emily T, Malosh Ryan E, Monto Arnold S, Lauring Adam S
Abstract excerpt
The evolutionary dynamics of influenza virus ultimately derive from processes that take place within and between infected individuals. Here we define influenza virus dynamics in human hosts through sequencing of 249 specimens from 200 individuals collected over 6290 person-seasons of observation. Because these viruses were collected from individuals in a prospective community-based cohort, they are broadly...
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