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Article

Adaptive selection of quasispecies during in vivo passaging in chickens, mice, and ferrets results in host-specific strains for the H9N2 avian influenza virus.

Journal of virology - 17 Jun 2025

Li Yiliang, Quan Xi, Chen Rujian, Wang Xiao, Chen Yiting, Gan Yingde, Irwin David M, Shen Yongyi

Abstract excerpt

Sporadic human infections of avian influenza virus (AIV) raise significant public health concerns. A critical factor limiting the transmission of AIVs is the shift in receptor-binding preference from Siaα2,3 to Siaα2,6. To reveal the adaptive selection dynamics during the host adaptation process of AIVs, this study generated a viral library with random mutations in the HA gene of the H9N2 strain. Upon passaging...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 40338080
DOI: 10.1128/jvi.00151-25
PMCID: PMC12172485

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TNF

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